Reduced CD56 NK cells in active GPA have an activated phenotype, which intriguingly is associated with profound deficiency in cytotoxicity.
These data suggest a function for NK cells in the pathogenesis and/or modulation of inflammation in GPA.
Background: The role of natural killer (NK) cells in granulomatosis with polyangiitis (GPA) is poorly understood.
We recently reported that peripheral blood NK cell percentages correlate with the suppression of GPA activity (cohort I).
Rudolf Kolbitsch Josef Huber Peter Dimmel Adolf Kloska Franz Fischbacher Fritz Aigner Anton Watzl Johannes Krejci Peter Kubovsky Margit Palme Alfred Würl Hermann Haider Norbert Drienko Thomas Pühringer Karl Hochgatterer Rudolf Kirchmayr Heinz Ritter Josef Wimmer Kurt Moldovan Barbara Hoffmann Ursula Schröcksnadel Siegfried Strasser Ewald Pirklbauer (Walser) Elfriede Trautner Erich Ruprecht Josef Häupl Gerhard Knogler Jan und Eva Schwankmayr Brigitte Wasmeyer Walter Breuer Richard Eder Gerlinde Grothe Josef Bauer Andreas Prag Peter Kraml Johann W.
CONTENTS OF DISK 1 ================== amigademo Graphical benchmark for comparing amigas. Author: Reinhold Weicker (Ada version) Rick Richardson (C version) dotty Source to the "dotty window" demo on the Workbench disk. Author: Landon Dyer make2 Another make subset command. "Portable" because the code itself is portable and because the archive format is very simple (uses ascii headers to separate files). Author: Martin Minow xrf C cross reference utility. Author: Bob Denny CONTENTS OF DISK 3 ================== gothic Gothic banner printer. Author: unknown roff A "roff" type text formatter, roughly following "Software Tools" version.
NK cell counts, but not other lymphocyte counts, were significantly higher in remission.
Author: Michael Mounier balls Simulation of the "kinetic thingy" with balls on strings where only the end balls move (quick, can YOU come up with a better description? Author Ken Yap ff A very fast text formatter, controlled exclusively by command line arguments.
Cytotoxicity assays were performed using 51Cr-labeled K562 target cells.
Multicolor analysis from cohort II revealed that in active GPA, the CD56dim subset was responsible for decreased NK cell counts, expressed more frequently CD69, downregulated the Fc-receptor CD16 and upregulated the adhesion molecule CD54, the chemokine receptor CCR5 and the activating receptor NKG2C.
Natural cytotoxicity was not detectable in most patients with active GPA, but was restored in remission.
Conclusions: NK cell numbers correlate inversely with GPA activity.Moderator: Watzl Vergleichsportale In diesem Board wird über die verschiedenen Vergleichsportale, welche Energiepreise der Lieferanten miteinander vergleichen, diskutiert.